Food-specific IgG is also present in healthy subject, but this important has not received much attention. Moreover, significantly higher serum food antigen-specific IgG positivity rates were found in patients with depressive disorder. Additionally, migraine patients with positive food specific IgG antibodies had worse migraine, anxiety, and gastrointestinal symptoms. Accordingly, IgG antibodies may potentially indicate disease status and be utilized to guide dietary recommendations for patients. ![]() ![]() Studies have found a high prevalence of serum IgG antibodies against specific food allergens in patients with IBD. Previous clinical studies on food-specific IgG typically focused on patients with a specific disease. The most direct evidence comes from an oral immunotherapy (OIT) study showing that OIT for peanuts can induce a remarkable increase in the plasma levels of food-specific IgG, which indicates the involvement of IgG in mitigating the symptoms and inducing food tolerance of allergic patients. According to other studies, however, food-specific IgG actually provides natural protection against food allergy. IgG antibody can form an immune complex with allergens in foods and thus induce mild inflammatory reactions in the body, which are manifested as various systemic symptoms and diseases. The symptoms of these disease can be relieved by food-specific IgG-based diet recommendations. Numerous studies have suggested that food-specific IgG is involved in the development and progression of specific diseases, such as inflammatory bowel disease, irritable bowel syndrome, migraine and mental disease. The Creative Commons Public Domain Dedication waiver ( ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.Īt present, the effects of food-specific IgG on human health remain controversial. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. ![]() Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made.
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